MCC CUREs are protein‐centric CUREs focusing on a variety of research areas related to Malate Dehydrogenase including mechanisms of catalysis and regulation, adaptation and evolution, cofactor specificity, folding and stability and interactions in metabolons, suitable for introductory to advanced level courses in diverse institutions.

 All CUREs implemented by MCC contain the same elements: Relevance, Scientific Background, Hypothesis Development, Proposal, Experiments/Teamwork to test hypothesis, Data Analysis and Conclusions, and Presentation, but differ in the extent of each between mCURE and cCURE

MCC CUREs are all based on the Hypothesis Development and Proposal module.

They can be full semester (Full CURE, cCURE), or part semester (Mini CURE, mCURE),  and can incorporate wet lab or computational approaches. Wet lab approaches can utilize existing validated constructs, or can create novel constructs, which in either case can be combined with expression and initial characterization of the expressed proteins to complete an mCURE. In a cCURE, these lead to a variety of experimental approaches organized around specific scientific clusters or themes where appropriate experiments to explore the student generated hypothesis can be found. Where no wet lab is feasible, the hypothesis development and proposal module can be linked to computational approaches to test the hypothesis to create dry lab mCUREs or cCUREs.

The Hypothesis Development and Proposal Module can be downloaded from the Resources page and its use in a variety of institutional settings ranging from Community College to Research Intensive Universities is described in our paper from CourseSource