https://www.mdhcurescommunity.org/what-we-do daily 0.75 2021-08-13 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1553458755075-KZ1OB6NHZU0Y1H88XCKW/CUREs+and+Modules_jkb.jpg What Are MCC CUREs Creating Wet or Dry Lab CUREs with MCC Resources https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1533412580463-YS1368N7CHYQDRDUSHRH/MCC+logo_2x_bonds.png What Are MCC CUREs https://www.mdhcurescommunity.org/partners daily 0.75 2021-01-03 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1533384865517-ZL808QITFM8YBAWLCDQD/IMG_0392.jpg Partner Institutions https://www.mdhcurescommunity.org/learning-goals-assessments daily 0.75 2020-11-21 https://www.mdhcurescommunity.org/virtual-cures-and-ures daily 0.75 2023-06-20 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1594943639047-AI0Z6JFBR6G6J3648RXG/roadmap.jpg Virtual CURES and URES RoadMap for CURE & URE Phases and Modules https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1594943575401-NY1PGS7M4D0FUTV6MUJ7/BAMBED_Title.jpg Virtual CURES and URES https://www.mdhcurescommunity.org/relevance daily 0.75 2023-07-18 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640980242417-K4L55HIW63ZHDGQC992F/syllabi.jpg Overview - Make it stand out Find Syllabi from a variety of full semester and modular MCC CUREs from a variety of institution types https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/6734d56f-329f-46dd-a625-0e97b64a6e8c/9-attributes-of-research.png Overview - Make it stand out Discussion of CURE Elements and teaching tips to incorporate these elements into your CURE. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640025118749-F2AFAVKBRXOXCY7YQPVW/mcc+banner-teach.jpg Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640980308421-N83OIUK4Q95OCVL4TE1R/pedagogy.jpg Overview - Make it stand out While MCC does not engage in Pedagogical Research, the OUR CUREs project does: if you are interested, get involved https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640989533995-8FVNBDGBYWFTFVVRY61F/buttons-virtual.jpg Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640980281752-KHL37TQA6OG7TAMJ7R2D/LOs.jpg Overview - Make it stand out Find examples of CURE Learning goals and assessments https://www.mdhcurescommunity.org/new-page-1 daily 0.75 2020-11-23 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1606164143665-4IZ1AH37VH10L6DNEWQ2/MCC1-leadership.jpg Leadership & Overall Organization https://www.mdhcurescommunity.org/subunit daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/page-x daily 0.75 2023-06-20 https://www.mdhcurescommunity.org/activesite daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/arabidopsis daily 0.75 2020-11-28 https://www.mdhcurescommunity.org/pfalci daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/resources daily 0.75 2021-08-17 https://www.mdhcurescommunity.org/mcc-discussion-board daily 0.75 2020-12-07 https://www.mdhcurescommunity.org/folding daily 0.75 2020-11-29 https://www.mdhcurescommunity.org/evolution daily 0.75 2020-11-29 https://www.mdhcurescommunity.org/extremophile daily 0.75 2020-11-29 https://www.mdhcurescommunity.org/faculty-only-password-required daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/mcc2021summermeeting daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/c1structures daily 0.75 2021-08-13 https://www.mdhcurescommunity.org/mutant-sequences daily 0.75 2022-01-21 https://www.mdhcurescommunity.org/home-alt-bedford daily 0.75 2021-08-17 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500612440-PGQSIY8KL9F7T5VIXQLO/chambers-2.jpg Home Alt A better world Starts with a choice Contact Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500503574-5BAPXZO9U06UV61P49UO/chambers1.jpg Home Alt Sustainability Starts with you Join Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500933384-LII4SRIPHFYOUFX0UCXC/chambers-4.jpg Home Alt A better world Starts with a choice Join Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390504287124-HQ8GNX1JCE22V047MSQ9/chambers-8.jpg Home Alt Preserve Nature Join Us https://www.mdhcurescommunity.org/wm-gmdhmutants daily 0.75 2023-04-12 https://www.mdhcurescommunity.org/basicenzymologyeb daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/basic-enzymology daily 0.75 2021-08-19 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629400044094-9MJP8Y7Y81OPTF9B735A/rossmann.png Basic Enzymology While MDHs contain a classic Rossmann Fold involved with cofactor binding, there is an additional helix (shown in gray). What role does it play in cofactor binding or associated conformational changes? https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629406331634-7QAE8SJ3PGU57QZ3WQ9I/NADP-chloro-etc.png Basic Enzymology - Chloroplastic NAD vs NADP Isoforms The Arabidopsis NADP specific enzyme (tan) has an overall similar dimer structure and conformation as the NAD specific isoform (blue). The location of potential redox regulated disulphides in the NADP specific isoform are shown in yellow https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629404322597-6KWVG6QZTH4OTTFODBFH/pf2.png Basic Enzymology - Make it stand out Combine computational and wet lab approaches to help design potential drugs for pathogenic species MDHs https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629406914273-QZYVMLMHSYVAYZO0VM14/interface+connections.png Basic Enzymology - Make it stand out Is there a molecular switch at the interface responsible for subunit interactions? https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629402883708-THG24SEBPP07S0ZHEP8I/citrate-induced.png Basic Enzymology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629407151839-4BA6FOWE4AJRFHONWF1Q/loops-turns.png Basic Enzymology - Are there connections between folding, dynamics and allostery? In addition to alpha helices and beta strands, malate dehydrogenase contains a number of turns (blue) and loops (pink). What roles do they play in structure function relationships? https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629404448737-2PCB0HIX7XOSAR9OS5FG/Islandicus+Tetramer.png Basic Enzymology - Tetrameric Malate Dehydrogenases such as that from Ignacoccus Islandicus off the challenge of understanding the roles of multiple interfaces as well as evolutionary relationships to other Malate Dehydrogenases and Lactate Dehydrogenase https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629397754402-IP8AZJ0MPX0G33B4FYOJ/active.png Basic Enzymology - Active Site (Catalysis) involves residues directly or indirectly responsibe for the hydride transfer and proton abstraction steps in the overall catalysis. While clear roles for several “first sphere” catalytic residues are well established, how “second sphere” residues contribute to either catalysis of allosteric interactions are unknown. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1629399014007-2A74ZNWT7UREL7OLUA3N/mobile-loop.png Basic Enzymology - Major Conformational Change Involves the flexible loop region, induced by cofactor/substrate binding. What interactions trigger the change? What parts of the loop govern substrate specificity? https://www.mdhcurescommunity.org/interfaces daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/citrate-regulation daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/loops-and-turns daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/rossmann-fold daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/arabidopsis-1 daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/pfalci-1 daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/mobile-loop-1 daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/ignacoccus daily 0.75 2021-08-19 https://www.mdhcurescommunity.org/what-is-mcc daily 0.75 2021-12-20 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640025781955-3TAVZ2K3Q1YTTEBAPFDR/MCC+Logo.jpg What is MCC? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1640025580463-UBA7WPWHBRP2TKAXW44F/video.jpg What is MCC? - Make it stand out Watch our NSF Video Showcase https://www.mdhcurescommunity.org/link-to-our-cures-pedagogical-research-projects daily 0.75 2023-05-03 https://www.mdhcurescommunity.org/new-page-33 daily 1.0 2025-05-20 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1642388313739-DIPFFHG48YLUR90OY37F/video.jpg New Page - Make it stand out Watch our NSF VideoShowcase Video, viewed over 8,000 times https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/2dc301b1-8c5a-40f0-b02c-bcd73ce6ecce/Protein+Society+Webinar+copy.png New Page - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/8de133cd-2f07-489b-b0ef-de6fb6a0c0c4/Bell+Labs+MCC+copy.png New Page - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/elements-of-mcc-cures daily 0.75 2023-07-09 https://www.mdhcurescommunity.org/new-page-55 daily 0.75 2021-12-12 https://www.mdhcurescommunity.org/well-educated-student daily 0.75 2023-07-29 https://www.mdhcurescommunity.org/projects-protocols_landing_page daily 0.75 2023-07-19 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641054917287-QXY7HPU2EOETU5HDB6FR/joe_buttom_project-images.jpg Introduction Research & Resources - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641054790138-N8UVPBHXU12475R3NLCT/MCC_Banner_IRR.jpg Introduction Research & Resources - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/mcc-clones daily 0.75 2022-11-23 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055778280-XLGB3CF1LPQWHYCJ0W1J/support.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055655051-39M8TGFG634KGD24M5UC/plant.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055757335-R29K6IOG93NBLOJRK909/bacteria.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055679426-CKEE5PGRMSOSUCJDFWKV/human.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055734920-YR2VK3Z9S0UU2YLIYRWW/extreme.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055803669-YZ93FXVII6N53KPA30R4/sdm.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1641055703803-WNL9Y4X64QPDTWDEY9QI/parasite.jpg MCC Clones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/plant2 daily 0.75 2022-08-04 https://www.mdhcurescommunity.org/human2 daily 0.75 2022-08-04 https://www.mdhcurescommunity.org/parasite2 daily 0.75 2022-08-04 https://www.mdhcurescommunity.org/extreme2 daily 0.75 2022-01-06 https://www.mdhcurescommunity.org/bacterium2 daily 0.75 2022-01-06 https://www.mdhcurescommunity.org/support2 daily 0.75 2022-01-06 https://www.mdhcurescommunity.org/sdm2 daily 0.75 2022-01-06 https://www.mdhcurescommunity.org/mdhbackground daily 0.75 2023-12-14 https://www.mdhcurescommunity.org/project-areas2 daily 0.75 2023-12-14 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1656443971522-O6LB7WC10W5MR0QX6Y7Q/coopetc.jpg Project Areas2 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/speccat daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/plantmdhs daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/drug-design daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/metabolonsppi daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/phosphorylationptms daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/expressionetc daily 0.75 2022-01-02 https://www.mdhcurescommunity.org/what-is-an-mcc-cure daily 0.75 2024-04-30 https://www.mdhcurescommunity.org/cohort-2022-application daily 0.75 2022-11-05 https://www.mdhcurescommunity.org/mcc-fellow-application daily 0.75 2022-01-22 https://www.mdhcurescommunity.org/atlantic-hub daily 0.75 2022-08-10 https://www.mdhcurescommunity.org/central-hub daily 0.75 2022-08-30 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1650758819036-HC3L9BG27HHB8OBAHF48/IMG_0261.JPG Central Hub - Make it stand out Students working with Betsy Martinez-Vaz, Tam Mans, and Lisa Gentile presenting their MDH-related research at the Winchell Undergraduate Research Symposium, Minnesota (Spring-2022) https://www.mdhcurescommunity.org/cohort-description daily 0.75 2023-04-07 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1667664627105-G381MI9PSV83HT2NL2QJ/fellows-page-2.jpg cohort description - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/fellows-description daily 0.75 2022-11-05 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1667664278988-23P8NBQM3SSXMPFEJRBY/fellows-page-4.jpg fellows description - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/western-hub daily 0.75 2022-08-24 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/1650752228335-NL1OEZH32JQYG9RAVDEF/2022_EB_ASBMB_Philadelphia1017.jpg Western Hub - Make it stand out Students and Faculty from USD: 4 MCC Related posters were presented at the 2022 American Society for Biochemistry and Molecular Biology Meeting. In addition Dr Joseph Provost, the recipient of the 2022 Education Award, highlighted MCC work in his Award Lecture. https://www.mdhcurescommunity.org/national-activities daily 0.75 2022-02-12 https://www.mdhcurescommunity.org/organization daily 0.75 2022-02-12 https://www.mdhcurescommunity.org/teamwork-collaboration daily 0.75 2022-01-22 https://www.mdhcurescommunity.org/loopongoing daily 0.75 2023-07-15 https://www.mdhcurescommunity.org/152l daily 0.75 2022-11-23 https://www.mdhcurescommunity.org/equipment-needs daily 0.75 2022-02-15 https://www.mdhcurescommunity.org/scientificbackground daily 0.75 2023-07-23 https://www.mdhcurescommunity.org/new-page-2 daily 0.75 2022-07-11 https://www.mdhcurescommunity.org/new-page-3 daily 0.75 2022-11-29 https://www.mdhcurescommunity.org/new-page-22 daily 0.75 2022-12-03 https://www.mdhcurescommunity.org/new-page-18 daily 0.75 2022-12-25 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/65061f57-698f-4f07-984e-b43308aa3292/research-elements+copy.jpg MCC Pedagogical Research Focus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/3fc65071-ed61-449f-8d72-827fc34a6520/MCCPedagogy+copy.jpg MCC Pedagogical Research Focus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/83b88aca-ab05-4387-990c-b08c66220bae/faculty-development+copy.jpg MCC Pedagogical Research Focus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/12f62cc3-84e3-43ea-b744-ac74e778f787/course-organization+copy.jpg MCC Pedagogical Research Focus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/ec9aded6-689a-4ade-ad2f-b03dc96cb3a2/learning+goals+copy.jpg MCC Pedagogical Research Focus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/developing-effective-faculty-development-for-cure-teaching daily 0.75 2022-12-03 https://www.mdhcurescommunity.org/curebackwarddesign daily 0.75 2022-12-25 https://www.mdhcurescommunity.org/exemplar-syllabi daily 0.75 2022-12-25 https://www.mdhcurescommunity.org/cure-design daily 0.75 2022-12-25 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/b640a3a8-8396-406c-90d9-774f8af3fac5/syllabi.jpg CURE Design - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/d829ab30-8205-4c2a-8d16-000e6a0cf9d3/Design.jpg CURE Design - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/c80df5c7-2b6a-49b8-bf87-2521f6bd8092/rubrics.jpg CURE Design - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/rubrics-for-cure-research-elements daily 0.75 2022-12-24 https://www.mdhcurescommunity.org/2023-meeting-program daily 0.75 2023-06-16 https://www.mdhcurescommunity.org/mcc-pedagogical-research-1 daily 0.75 2023-06-18 https://www.mdhcurescommunity.org/new-nci-etc daily 0.75 2024-04-30 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/4e4a148b-e2b0-4e03-99d7-7a070b6c3f7b/projects-techniques.png How to Incorporate CURE Pedagogy into CUREs involving Noncovalent Interactionsteractions - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mdhcurescommunity.org/new-page-54 daily 0.75 2023-06-09 https://www.mdhcurescommunity.org/teaching-an-mcc-cure daily 0.75 2024-04-30 https://www.mdhcurescommunity.org/peer-review daily 0.75 2023-07-09 https://www.mdhcurescommunity.org/intro_2_mdh daily 0.75 2023-07-15 https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/f22ec61f-5a63-4955-991c-19c543993cd3/Intro-2.png Intro_2_MDH - Make it stand out The Hydrogen on the C2 carbon of Malate is transferred as a hydride ion (H-) to the 4-Carbon of the nicotinamide ring of the cofactor NAD+ to give NADH. During the process a proton is also released to the solvent. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/59e0776a-cdc0-4e87-9356-792d80a0af40/Intro-4.png Intro_2_MDH - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/a58391eb-7133-486f-b2cb-d7bf2b9bb028/Intro-3.png Intro_2_MDH - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/2c3eb8d3-05a1-4a53-abb5-8b0e5c218f3c/Intro-5.png Intro_2_MDH - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b5b5fa95cfd794420456b01/7e7356fc-d983-43e2-b74b-71579ed76b13/Intro-1.png Intro_2_MDH - Make it stand out involving a simple hydride transfer from the 2 position of Malate to NAD+ to form the reduced cofactor NADH. 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