Extremophile Microbes

9CREN aka A0A0U3FQH7_9CREN (A0A0U3FQH7).  Cloned from sulfidogenic, chemolithoautotrophic Ignicoccus islandicus a novel genus of hyperthermophilic, chemoliphoautorophic Archaea growing in a ~90oC hydrothermal vent. This is an NADHP dependent tetramer with LDH like activity.  May be a divergent homolog from MDH and LDH with different allosteric properties.   (DataSheet / SnapGeneFile)

MDH_HALMA Cloned from Haloarchula marismortui  a Dead Sea Halobactrium Red Archaeon. The quaternary structure is stabilized by chloride ions bound between the subunits. This may be an adaptation to the halophilic environment. Sequence is similar to LDH, more than other MDH isoforms. Generates an active tetramer upon ~3-4M NaCl.  (DataSheet / SnapGeneFile)

MDH_AQUAR Aquaspirillum arcticum - Bactrium isolated from under snow and ice in the northwest territory of Canada. The sequence of this MDH is highly related to thermophilic MDH.  This protein is 2-3 fold more active at 4-10oC than other MDH enzymes – possibly due to an increased flexibility at the active site as well as possible reduced interactions at subunits.  (DataSheet / SnapGeneFile)